Mitochondrial Remodeling After Exercise

Oregon State University (OSU)

Status: Completed

Conditions: Insulin Resistance; Overweight and Obesity; Mitochondrial Metabolism; Sedentary Lifestyle; Metabolic Disease

Treatments: Behavioral: Short-term Exercise Training

Study type: Interventional

Funder types: Other

Identifiers

NCT04103424

IRB-2019-0124

Details and patient eligibility

About

Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.

Enrollment: 31 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-45 years
• Body mass index (BMI) 18-45 kg/m2
• Sedentary (<1 hour of planned exercise per week)

Exclusion criteria

• Regular exercise (>1 hour of planned exercise per week)
• Smoking, tobacco or nicotine use within the last 1-year
• Fasting glucose >126mg/dL
• Hypertension (systolic pressure >140 mmHg or diastolic pressure >90 mmHg)
• Chronic metabolic or cardiovascular health conditions
• Pregnant, nursing, irregular menses or post-menopausal
• Lidocaine allergy
• Certain medications
• Physical limitations that prevent safe or successful exercise completion
• Diminished capacity for consent

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

31 participants in 2 patient groups

Pre-training Metabolic Study Visit

No Intervention group

Description:

Participants will first complete a pre-training metabolic study visit.

Post-training Metabolic Study Visit

Experimental group

Description:

Participants will complete a second, identical metabolic study visit following 2-weeks of exercise training.

Treatment:

Behavioral: Short-term Exercise Training