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Mivacurium 0.2 mg/kg in Young (18 - 40 Years) and Elderly (= 80 Years) Patients

M

Matias Vested

Status

Completed

Conditions

Onset Time of Mivacurium, Duration of Action of Mivacurium

Treatments

Drug: Mivacurium

Study type

Observational

Funder types

Other

Identifiers

NCT05558137
H-22028734

Details and patient eligibility

About

The aim of this study is to determine the onset time, duration of action and effect on intubation conditions of mivacurium 0.2 mg/kg in elderly patients with age ≥ 80 years and in young patients aged 18 - 40 years.

Full description

The aim of this study is to determine the onset time, duration of action and effect on intubation conditions of mivacurium 0.2 mg/kg in elderly patients with age ≥ 80 years and in young patients aged 18 - 40 years. The hypothesis of this study is that mivacurium administered in elderly patients (>80 years) has a longer onset time and duration of action compared to younger patients.

Enrollment

70 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Patients ≥ 80 or ≥ 18 to ≤ 40 years of age
  2. Informed consent
  3. Scheduled for elective surgery under general anaesthesia (expected duration of anaesthesia > 1 hour) with intubation and use of mivacurium
  4. American Society of Anesthesiologists (ASA) physical status classification I to III
  5. Can read and understand Danish

Exclusion criteria

  1. Known allergy to mivacurium
  2. Neuromuscular disease that may interfere with neuromuscular monitoring
  3. Indication for rapid sequence induction
  4. Surgery in the prone position
  5. Known butyrylcholinesterase deficiency

Trial design

70 participants in 2 patient groups

Elderly
Description:
patients aged 80 years or older
Treatment:
Drug: Mivacurium
Young
Description:
patients aged 18-40 years
Treatment:
Drug: Mivacurium

Trial contacts and locations

1

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Central trial contact

Matias Vested

Data sourced from clinicaltrials.gov

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