Mixed Local for Sciatic Block

Lawson Health Research Institute

Status: Not yet enrolling

Conditions: Local Anesthetic; Regional Anesthesia

Treatments: Drug: Ropivacaine 0,5%; Drug: Ropivacaine and Lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT06671028

125572

Details and patient eligibility

About

Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration. On the other hand, long acting local anesthetics while provides long duration suffered from long onset time. The ideal local anesthetics should provide faster nerve block onset while providing reasonable duration to provide sustained postoperative analgesia. Mixing short and long acting local anesthetics for nerve blocks may appear to be the solution however previous published studies have demonstrated similar onset time to long acting local anesthetics and with reduced duration. Recently, the London Health Sciences Centre established an ambulatory surgical centre. Fast onset peripheral nerve block is desirable. Previous studies have not looked at popliteal sciatic block and anecdotally we feel addition of short acting local anesthetics appear to speed up onset. We are therefore interested in conducting a randomize trial to determine whether mixing short and long acting local anesthetics can speed up onset of surgical quality block.

Enrollment: 110 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (≥18 years old)
• Scheduled for elective below-knee surgeries such as ankle arthroscopy, lower limb fracture fixation, toe surgeries, etc
• Capable of providing informed consent

Exclusion criteria

• History of allergic reaction to local anesthetics
• Pre-existing neurological disorders affecting lower limbs
• Significant renal or hepatic impairment
• Pregnancy or breastfeeding
• Less than 60kg
• Inability to provide informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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110 participants in 2 patient groups

Ropivacaine

Active Comparator group

Description:

Popliteal block using Ropivacaine 100 mg in 20 mL

Treatment:

Drug: Ropivacaine 0,5%

Ropivacaine anmd Lidocaine

Experimental group

Description:

Popliteal sciatic block using Ropivacaine 100 mg and Lidocaine 100 mg in 20 mL

Treatment:

Drug: Ropivacaine and Lidocaine