MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer

Pediatric Brain Tumor Consortium

Status and phase

Terminated

Phase 1

Conditions

Brain and Central Nervous System Tumors

Treatments

Drug: MK-0752

Study type

Interventional

Funder types

NETWORK

NIH

Identifiers

NCT00572182

U01CA081457 (U.S. NIH Grant/Contract)

CDR0000578114

PBTC-024 (Other Identifier)

NCI-09-C-0112

Details and patient eligibility

About

RATIONALE: MK0752 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

PURPOSE: This phase I trial is studying the side effects and best dose of MK0752 in treating young patients with recurrent or refractory CNS cancer.

Full description

OBJECTIVES:

Primary

To estimate the maximum tolerated dose (MTD) and recommended phase II dose of MK0752 administered for 3 consecutive days of every 7 days in 28 day courses to young patients with recurrent or refractory CNS malignancies (Dosing regimen 1 - closed to accrual 2/23/2010).
To estimate the MTD and recommend a phase II dose of MK0752 administered once weekly in 28 day courses to young patients with recurrent or refractory CNS malignancies (Dosing regimen 2).
To compared the MK0752 systemic exposure attained with each dosage level on the different dosing regimens.

Secondary

To characterize the pharmacokinetics of MK0752.
To document and describe toxicities associated with MK0752.
To preliminarily define the antitumor activity of MK0752 within the confines of a phase I setting.

OUTLINE: This is a multicenter, dose-escalation study.

Patients receive oral MK0752 once daily on days 1-3, 8-10, 15-17, and 22-24 (dosing regimen 1 - closed to accrual 2/23/2010) or days 1, 8, 15, and 22 (dosing regimen 2). Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Treatment may be extended up to 19 courses if the patient is benefitting from the treatment.

Patients undergo blood sample collection periodically for pharmacokinetic studies.

After completion of study treatment, patients are followed for 30 days.

Enrollment

33 patients

Sex

All

Ages

3 to 21 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Histologically confirmed primary CNS tumor
- Patients with intrinsic brain stem tumors do not require histologic verification, but must have radiographic evidence of progression
Recurrent disease or refractory to standard therapy
No histologically benign brain tumors (e.g., low-grade glioma)

PATIENT CHARACTERISTICS:

Karnofsky performance status (PS) or Lansky PS 60-100%
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception
Absolute neutrophil count ≥ 1,000/μL
Platelet count ≥ 100,000/μL (unsupported)
Hemoglobin ≥ 8 g/dL (RBC transfusions allowed)
Creatinine clearance OR glomerular filtration rate ≥ 70 mL/min OR serum creatinine based on age as follows:
- 0.8 mg/dL (≤ 5 years of age)
- 1.0 mg/dL (> 5 to ≤ 10 years of age)
- 1.2 mg/dL (> 10 to ≤ 15 years of age)
- 1.5 mg/dL (> 15 years of age)
Bilirubin ≤ 1.5 times upper limit of normal (ULN) for age
ALT ≤ 2.5 times ULN for age
Albumin ≥ 2.5 g/dL
Sodium, potassium, magnesium, and calcium normal
Patients with neurological deficits are eligible provided these deficits are stable for ≥ 2 weeks prior to study registration
No clinically significant systemic illness (e.g., serious infection or significant cardiac, pulmonary, hepatic, or other organ dysfunction) that would compromise the patient's ability to tolerate study therapy or would likely interfere with the study procedures or results
No known hypersensitivity to MK0752

PRIOR CONCURRENT THERAPY:

Recovered from the acute toxic effects of all prior therapy
At least 3 weeks since prior myelosuppressive anticancer chemotherapy (6 weeks for nitrosoureas)
At least 7 days since prior investigational or biologic agents
- At least 3 weeks since prior investigational or biologic agents that have a prolonged half-life or for which the patient has experienced ≥ grade 2 myelosuppression in the treatment course preceding discontinuation of therapy
At least 3 half lives since prior monoclonal antibody therapy
At least 6 months since prior total body irradiation or craniospinal radiotherapy
At least 6 weeks since other prior substantial bone marrow irradiation
At least 2 weeks since prior local palliative radiotherapy (small volume)
At least 6 months since prior allogeneic bone marrow transplantation (BMT)
- No evidence of active graft versus host disease
At least 3 months since prior autologous BMT or stem cell transplantation
At least 7 days since prior hematopoietic growth factors (filgrastim [G-CSF], sargramostim [GM-CSF], or erythropoietin) (14 days for long-acting formulations)
No prior MK0752
No concurrent enzyme-inducing anticonvulsant drugs (EIACDs)
No other concurrent anticancer or investigational drug therapy
Concurrent dexamethasone allowed provided patient is on a stable or decreasing dose for ≥ 2 weeks prior to study registration