MK0782 + Low-Dose Aspirin 7-Day Erosion Endoscopy Study (0782-001)

Merck Sharp & Dohme (MSD)

Status and phase

Completed

Phase 2

Conditions

Duodenal Ulcer

Stomach Ulcer

Treatments

Drug: MK0782

Study type

Interventional

Funder types

Industry

Identifiers

NCT00543868

2007_637

0782-001

Details and patient eligibility

About

This study will determine how if MK0782 is safe and tolerable and to determine how often and the severity of stomach and small intestine ulcers develop following administration of MK0782 plus enteric coated aspirin, rofecoxib 25mg plus enteric coated aspirin, naproxen 500 mg puls enteric coated asprin vs placebo.

This is an early phase trial and some specific protocol information is in progress and not publicly available at this time. (Full information is available to trial participants).

Enrollment

462 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy male or non pregnant female
18 years of age or older (age at consent)
Able to abstain from alcohol, tobacco, spicy foods, limit coffee
Able to avoid strenuous activity
Able to read and fill out a study diary

Exclusion criteria

You have participated in an investigational drug study within 4 weeks of entering this study
Your weight is not within a specific range for the study
You have a history of GI problems like a gastric ulcer
You have had gastric or intestinal surgery
You have had abdominal or chest surgery
You are currently abusing drugs or alcohol or have a history of abuse
You have a history of psychiatric disorders
You are a smoker or have smoked during the last year