MK0954A-264 Filter Study (0954A-264)(COMPLETED)

Organon

Status and phase: Completed; Phase 3

Conditions: Mild to Severe Hypertension

Treatments: Drug: MK0954A, hydrochlorothiazide (+) losartan potassium / Duration of Treatment: 6 weeks; Drug: losartan / Duration of Treatment: 6 weeks

Study type: Interventional

Funder types: Industry

Identifiers

NCT00307060

0954A-264

2006_019

Details and patient eligibility

About

To compare the blood pressure lowering efficacy, safety and tolerability of a combination drug to a single drug taken once daily in patients with uncontrolled blood pressure following a 4-week filter on the single therapy product.

Enrollment: 274 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male and female patients with mild to severe hypertension (SiDBP 90-120 mmHg)

Exclusion criteria

• Systolic BP > 200 mmHg
• Secondary or malignant hypertension
• Taking more than 2 antihypertensive medications
• Hypertension induced by oral contraceptives
• Hx of cerebral vascular accident within 6 months
• Hx of angina, myocardial infarction, PCI, CABG, or decompensated CHF within 6 months
• Clinically significant AV conduction disturbance or potentially life threatening ventricular arrhythmias, valvular disease, cardiomyopathy, unexplained syncope
• History of angioedema
• Sensitivity to AII receptor antagonists or HCTZ, nephrotic syndrome,single kidney function
• Pregnancy or lactation.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind