MMP-7 Modulation by Short and Long Term Radiotherapy in Rectal Cancer Patients

Region Skane

Status: Completed

Conditions: Rectal Cancer

Treatments: Radiation: Neoadjuvant radiotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT03151759

LU155-01

Details and patient eligibility

About

To analyse the effects of radiation therapy on inflammation and matrilysin levels in rectal cancer patients.

Enrollment: 77 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Adenocarcinoma of the rectum, ability to understand written and oral information, written consent.

Exclusion criteria

Colon cancer, benign tumors, impaired general condition of patient, declining to participate in the study, synchronous colonic tumors, logistical reasons, inability to understand written and/or oral information, previous pelvic irradiation, ongoing immunosuppressive therapy, diabetes with systemic complications.

Trial design

77 participants in 3 patient groups

No radiotherapy

Description:

Surgery only

25 Gray radiotherapy

Description:

Surgery after short term radiotherapy

Treatment:

Radiation: Neoadjuvant radiotherapy

50 Gray radiotherapy

Description:

Surgery after long term radiotherapy

Treatment:

Radiation: Neoadjuvant radiotherapy