MMP-9 Monitoring Particulate Cerebral Embolisation (MMP9MPCE)

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: Cerebral Embolic Damage

Treatments: Procedure: vein blood collection

Study type: Observational

Funder types: Other

Identifiers

NCT02109120

PUMCH-0321

Details and patient eligibility

About

1. In carotid endarterectomy(CEA) surgery, the dynamic changes of plasma MMP9 concentration cross CEA will be identified.
2. And the part of patients suffered particulate cerebral embolic injury, their MMP9 level will increase in the early stage after CEA.

Enrollment: 48 patients

Sex: All

Ages: 40 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

-All patients enrolled had at least ≥70% unilateral or bilateral stenosis of Internal -Carotid Artery， or those who had a <70% stenosis but obvious cerebral ischema symptoms had been existed.

Exclusion criteria

• Exclusion criteria included poor temporal window
• Refused to cooperate with us
• Nonatheromatous such as takayasu arteritis and fibromuscular dysplasia.

Trial design

48 participants in 1 patient group

carotid endarterectomy (CEA)

Description:

CEA patients with vein blood collection

Treatment:

Procedure: vein blood collection