Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment (MST training)

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VA Office of Research and Development

Status

Completed

Conditions

Mild Cognitive Impairment

Treatments

Behavioral: mnemonic strategy training
Behavioral: spaced retrieval training

Study type

Interventional

Funder types

Other U.S. Federal agency

Identifiers

NCT04533204
B6366-W-1

Details and patient eligibility

About

This study compared two active cognitive interventions to evaluate whether one improved memory more than the other in patients with mild cognitive impairment. Participants were randomized to either memory strategy training or spaced retrieval training and completed memory tests before and after 3 training sessions. Participants returned 1 month after treatment to see how well they remembered the learned information. Brain scans (functional MRI) were collected before and after the interventions to see if training changed the way brain regions were functioning.

Full description

Individuals with MCI were randomized to 3 sessions of mnemonic strategy or spaced retrieval training that focused on object location associations. Across these training sessions, each group received 9 training trials for each of the 45 trained stimuli. Task-fMRI was acquired before and after training. Memory was again evaluated 1 month after the last training session. The primary outcome measure was memory for the "trained" stimuli while secondary outcome was accuracy for novel stimuli acquired outside of the MRI environment.

Enrollment

59 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

-Diagnosis of MCI according to Petersen (2004) criteria, right handed

Exclusion criteria

  • Diagnosis of other neurological condition,
  • active drug/alcohol abuse/dependence,
  • moderate-severe depression or other Axis I diagnoses.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

59 participants in 2 patient groups

Mnemonic strategy training
Experimental group
Description:
Training using mnemonic strategies
Treatment:
Behavioral: mnemonic strategy training
Spaced retrieval training
Active Comparator group
Description:
Training using spaced retrieval
Treatment:
Behavioral: spaced retrieval training

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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