mNGS for Detection of Pathogens for Pulmonary Infection
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About
Pulmonary infections remain the leading causes of morbidity and mortality among patients worldwide. Pathogen identification is crucial yet difficult for the majority of the cases. Metagenomic Next-generation Sequencing provides a potential technology for rapid and untargeted pathogen detection for pulmonary infection. The study is designed observationally to investigate if mNGS is superior to traditional paradigm of serial tests in the aspect of diagnostic performance. Patients whose primary diagnosis is pulmonary infetion and bronchoalveolar lavage fluid can be obtained will be enrolled. Both mNGS and traditional paradigm of serial tests wil be performed.
Enrollment
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Inclusion criteria
- Pulmonary infection as the primary diagnosis
- Bronchoalveolar lavage fluid can be obtained
Exclusion criteria
- when the primary diagnosis is tumor or connective tissue diseases
- microbiological diagnosis is confirmed before bronchoalveolar lavage
- not enough bronchoalveolar lavage fluid for mNGS
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Data sourced from clinicaltrials.gov
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