mNGS Versus Blood Culture in FN

Peking University

Status: Unknown

Conditions: Febrile Neutropenia; Infections; Hematologic Diseases

Treatments: Diagnostic Test: blood culture versus mNGS detection

Study type: Observational

Funder types: Other

Identifiers

NCT05149547

mNGS for FN(2021PHB362-001)

Details and patient eligibility

About

Blood stream infection (BSI) during febrile neutropenia (FN) is a lethal complication, while confirmed diagnosis via blood culture is usually with low sensitivity and time delay. The new technique of metagenome next generation sequencing (mNGS) has the potential of early and more accurate detection of pathogens. However, this technique has not been well validated for BSI diagnosis in patients with hematological disease. Therefore, we designed a prospective multicenter study to compare the diagnosis performance in BSI.

Enrollment: 300 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hematologic disease
• febrile neutropenia

Exclusion criteria

• refuse to consent
• age<=14
• not caused by infection