mNGS Was Applied to the Study of Pathogen Identification, Precision Medication and Efficacy Evaluation of Infected Patients

Shanghai Jiao Tong University

Status: Unknown

Conditions: mNGS

Treatments: Diagnostic Test: mNGS

Study type: Interventional

Funder types: Other

Identifiers

NCT04310657

mNGS

Details and patient eligibility

About

1. prospectively collected the patients with the proposed infection, confirmed the infection or excluded the infection through mNGS detection combined with traditional pathogen detection methods and clinical characteristics, compared the detection performance of mNGS and traditional methods, and explored the significance of mNGS microbial map characteristics for the diagnosis/exclusion of infection; 2) real-time dynamic monitoring of the pathogen and microecology of infected patients during the targeted drug use, and evaluation of the efficacy in combination with other indicators; 3) to explore the significance of the number of pathogen sequences before the clinical withdrawal of drugs to the clinical practice.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 to 75 years old
• expected length of stay in ICU was > 24 h
• suspected infected patients (PSI or CPIS, qSOFA or SIRS)

Exclusion criteria

• Pregnant and lactating women
• Who has not signed the informed consent
• the researchers considered that others were not suitable for the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Precision therapy

Experimental group

Treatment:

Diagnostic Test: mNGS

control

No Intervention group