Mobile MRI for Immediate Radiological Acute Cerebral Lesion Evaluation in Stroke (MIRACLES)

NHS Trust

Status: Enrolling

Conditions: Stroke, Acute

Treatments: Device: Mobile MRI scanner

Study type: Observational

Funder types: Other

Identifiers

NCT06262217

INGN21ST510

Details and patient eligibility

About

This prospective observational study will evaluate the potential value of mobile MRI in patients with suspected or proven acute stroke and Transient Ischemic Attack (TIA), undertaking additional imaging in the emergency department, acute stroke unit, or outpatient settings, and comparing diagnostic accuracy, Diffusion-weighted imaging (DWI) lesion volume and detection of complications (brain swelling or haemorrhagic transformation). Information on ease of use, tolerability and image quality will also be gathered.

Full description

The study will investigate mobile MRI for immediate radiological acute cerebral lesion evaluation in Stroke. The objectives are:

1. Among patients with possible acute minor stroke or TIA, to compare the detection rate of acute DWI lesions on mobile MRI scan with routine imaging, describe number and distribution of lesions, and describe the intervals between mobile MRI and routine diagnostic scan, and time to final clinical diagnosis
2. Among patients with acute stroke of uncertain onset time, to compare the presence of DWI-Fluid attenuated inversion recovery (FLAIR) mismatch pattern on mobile MRI with CT perfusion (CTP) mismatch.
3. Among patients with confirmed acute ischaemic stroke, to compare the volume of DWI lesion on mobile MRI with the core volume on CTP
4. Among patients with established stroke post-thrombolysis or thrombectomy, to compare the incidence of brain swelling and haemorrhagic transformation on mobile MRI with routine imaging
5. In all groups, to evaluate the tolerability and ease of use of the mobile MRI scanner, and to rate image quality

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or non-pregnant female > or = 18 years of age
• Clinically suspected stroke or transient ischaemic attack, or confirmed clinical diagnosis of stroke or TIA
• Consent of patient or legal representative

Exclusion criteria

• Contraindications to MRI brain scan as per standard MRI checklist for NHS Greater Glasgow & Clyde

Trial design

200 participants in 1 patient group

Mobile MRI

Description:

Mobile MRI scan

Treatment:

Device: Mobile MRI scanner