Model-Based Image Reconstruction for X-Ray CT in Lung Imaging

University of Michigan

Status and phase: Completed; Phase 1

Conditions: Lung Diseases

Treatments: Procedure: CT Imaging and Reconstruction

Study type: Interventional

Funder types: Other; Industry; NIH

Identifiers

NCT01979991

HUM00038447

Details and patient eligibility

About

To develop a computer program that will improve CT image quality and decrease the amount of x-ray radiation that future patients may be exposed to when they have a CT examination.

Full description

We will be asking patients for their permission to save and use the sinogram from their CT scan. The sinogram will be de-identified and sent to an archive system for storage. It will be exported to a computer for processing using MBIR (model based iterative reconstruction). MBIR (model based iterative reconstruction) is a new method being developed to process CT sinograms. The newly reconstructed images will be reviewed by experts to determine if they are as readable and accurate as CT images created with the software that is currently being used. Sinogram data and the reconstructed images will be shared with collaborating researchers at General Electric Global Research.

Enrollment: 184 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 18 years of age and older 2. No medical or psychiatric condition precluding informed consent

Exclusion criteria

1. Inability to lie flat on the back with arms raised over the head for 30min.
2. Metallic implants or metallic devices in the chest or back.
3. Participation in other research trials involving ionizing radiation

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

---

184 participants in 1 patient group

CT Imaging and Reconstruction

Experimental group

Description:

To develop a MBIR (model-based image reconstruction) method that will improve X-ray CT lung imaging by improving image quality and reducing dose.

Treatment:

Procedure: CT Imaging and Reconstruction