Model of Predicting Biochemical Recurrence After Radical Prostate Cancer Based on Pre-treatment PSMA PET / MR Image Features

Shanghai Jiao Tong University

Status: Completed

Conditions: Prostate Cancer

Treatments: Other: Observe

Study type: Observational

Funder types: Other

Identifiers

NCT06604377

RuijinH 2024-244

Details and patient eligibility

About

The purpose of this study is to investigate the predictive value of preoperative 18F-PSMA-1007 PET/MR in the predictive effect of biological recurrence (BCR) after radical prostatectomy (RP) for localized prostate cancer (PCa).

Full description

Construct a predictive model for biochemical recurrence (BCR) in patients after radical prostatectomy using imaging parameters from preoperative 18F-PSMA-1007 PET/MRI, and compare the predictive performance of this model with existing clinical models. Data from three centers will be collected, with datasets from two centers used as the training set for the selection of predictive factors and model construction, while the dataset from the remaining center will serve as the validation set to assess the predictive performance of the model for BCR after prostatectomy.

Enrollment: 203 patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥ 18 years
2. Histologically confirmed prostate cancer without other types of malignancy -

Exclusion criteria

1.Surgery or endocrine therapy is performed prior to the examination

Trial design

203 participants in 1 patient group

Shanghai East Hospital, Tongji University School of Medicine

Description:

Patients diagnosed with prostate cancer undergoing PSMA PET/MR examination prior to surgery.

Treatment:

Other: Observe