Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in Obsessive-compulsive Disorder(OCD) Patients

Seoul National University

Status: Completed

Conditions: OCD

Study type: Observational

Funder types: Other

Identifiers

NCT01936051

H-1109-086-378

2011-0931 (Other Identifier)

Details and patient eligibility

About

To modeling the pharmacokinetic-pharmacodynamic(PK-PD) simulation with the plasma concentration and the transporter occupancy from OCD patients treated with escitalopram.

To examine the effect of G2677T/A single nucleotide polymorphism(SNP) of ABCB1 gene to the PK-PD modeling in OCD patients treated with escitalopram.

Full description

To measure plasma concentration of escitalopram in OCD patients treated with escitalopram.

To measure serotonin transporter occupancy by escitalopram in OCD patients treated with escitalopram.

To genotype G2677T/A SNP of ABCB1 gene in OCD patients treated with escitalopram.

Enrollment: 12 patients

Sex: Male

Ages: 20 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of OCD based on Diagnostic and Statistical Manual(DSM)-IV criteria
• no change of escitalopram dosage in 6 weeks

Exclusion criteria

• psychiatric comorbidity other than OCD
• History of head injury, epilepsy, other general medical disorder

Trial design

12 participants in 1 patient group

OCD patients

Description:

OCD patients being treated with any dose of escitalopram