Modeling Blood Management and Hemolytic Risk in Pediatric Heart Surgery

Boston Children's Hospital

Status: Enrolling

Conditions: Hemolysis; Heart Surgery; Blood Transfusion

Treatments: Other: blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT06721455

IRB-P00049726

Details and patient eligibility

About

This study aims to learn more about blood management in children undergoing heart surgery, such as the right amounts, and the best blood products, to administer. It also aims to develop a mathematical model that may help researchers better predict and treat patients who need blood transfusions during heart surgery.

Enrollment: 50 estimated patients

Sex: All

Ages: Under 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• pediatric patients under 18 years of age undergoing cardiac surgery with clear prime on cardio-pulmonary bypass (CPB) at Boston Children's Hospital (BCH).

Exclusion criteria

• patients with known hemolytic disorders, patients on nitric oxide preoperatively, and patients found to have abnormal coagulation on routine preoperative assessment. Patients receiving heparin, American Society of Anesthesia (ASA) status, apixaban, warfarin, or bivalirudin held appropriately (i.e. for elective surgery) will not be excluded

Trial design

50 participants in 1 patient group

Children having heart surgery

Description:

Children under 18 years of age having heart surgery with cardio-pulmonary bypass at Boston Children's Hospital

Treatment:

Other: blood sampling