Modeling of Regional Citrate Anticoagulation With a Dialysate Containing Calcium in Intermittent Hemodialysis (MARC)

University Hospital, Clermont-Ferrand

Status: Completed

Conditions: End Stage Renal Disease

Treatments: Other: blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT04530175

2020-A01359-30 (Other Identifier)

RBHP 2020 ANIORT

Details and patient eligibility

About

The primary purpose of this study is to validate a mathematical modeling of treatment by intermittent hemodialysis using regional citrate anticoagulation with a dialysate containing calcium

Full description

The only visit to the study will be carried out during a usual dialysis session in the intensive care unit of Clermont-Ferrand University Hospital. In addition to the usual care, 2 blood samples will be taken from the blood circuit 1 hour after the start of the hemodialysis session by the nurse in charge of the patient.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major patient;
• Man or woman ;
• Treated with intermittent hemodialysis for chronic renal failure;
• In whom intermittent hemodialysis with citrate solution for regional anticoagulation is indicated;
• Affiliated with a social security scheme;
• Having given a signed agreement after detailed explanation of the protocol on the basis of the information sheet and likely to comply with it

Exclusion criteria

• Severe hepato-cellular insufficiency (PT <50%, INR> 1.5 without anticoagulant);
• Hemoglobin level <7 g / dL
• Presenting a psychiatric pathology or cognitive impairment rendering him unable to give informed consent;
• Persons under guardianship, curatorship, deprived of liberty or safeguard of justice
• Pregnant or breastfeeding women
• Patient's refusal to participate in the study.

Trial design

30 participants in 1 patient group

patients with hemodialysis

Description:

patient treated with intermittent hemodialysis for chronic renal failure

Treatment:

Other: blood sampling