Modeling the Neurological Basis and Characterizing the Neurological Phenotype of Obesity Using Human Neural Stem Cells

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University of California San Diego

Status

Terminated

Conditions

Obesity, Morbid

Treatments

Procedure: Bariatric Surgery
Drug: Anti Obesity Drugs

Study type

Observational

Funder types

Other

Identifiers

NCT03263390
170097

Details and patient eligibility

About

This study aims to characterize the neurological basis of obesity and response to surgical and medical treatment by inducing adult pluripotent stem cells into neuronal cells from subjects that have demonstrated extreme response to bariatric surgery or pharmacological treatment for obesity.

Full description

The investigators will consent subjects who have achieved extreme response to either bariatric surgery or pharmacologic treatment for obesity and harvest fibroblasts from skin biopsies, which will be reprogrammed to induced pluripotent stem cells (iPSC). These iPSC's will then be differentiated into neural progenitor cells, neurons, astrocytes, and microglia to identify genetic and epigenetic pathways altered in disease-specific neural progenitor cells of the brain.

Enrollment

6 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • History of obesity
  • Treatment with bariatric surgery
  • Treatment with anti obesity medications
  • Greater than 70% excess weight loss at least 6 months after surgery
  • Greater than 15% weight loss on anti obesity medications

Exclusion criteria

  • Active cancer, not including non-melanoma skin cancer
  • Active eating disorder
  • Use of anti obesity medications in subjects with a history of bariatric surgery
  • Active complication of the upper GI tract in patients with a history of bariatric surgery

Trial design

6 participants in 2 patient groups

Bariatric Surgery
Description:
Subjects that have demonstrated extreme response to bariatric surgery.
Treatment:
Procedure: Bariatric Surgery
Anti Obesity Medications
Description:
Subjects that have demonstrated extreme response to anti obesity pharmacotherapy.
Treatment:
Drug: Anti Obesity Drugs

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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