Moderate-Intensity Exercise and Pain Sensitization in Breast Cancer Survivors: A Case-Based Study

Universidad Rey Juan Carlos

Status: Enrolling

Conditions: Breast Cancer; Exercise Training; Pain Management

Treatments: Other: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT07128030

EDCM

Details and patient eligibility

About

The aim of this study was to evaluate the feasibility, safety, and acceptability of a supervised, combined moderate-intensity aerobic and resistance training program designed to reduce pain sensitization in BCS with persistent pain. Secondary objectives included assessing changes in pain intensity, somatosensory sensitivity, and temporal summation, while tertiary objectives focused on improvements in quality of life and functional capacity.

Enrollment: 10 estimated patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult women diagnosed with stage I-III breast cancer
• Completion of active treatment (surgery, chemotherapy, and/or radiotherapy) at least 6 months prior to enrollment
• Presence of persistent pain or altered sensation in the upper quadrant of the affected limb related to oncologic treatment

Exclusion criteria

• Bilateral breast cancer
• Locoregional recurrence
• Other malignancies
• Pre-existing pain not related to cancer treatment
• Neurological or cognitive disorders
• Non-Spanish speakers
• Contraindications to moderate-intensity physical activity

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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10 participants in 2 patient groups

Moderate-Intensity Exercise

Experimental group

Description:

The experimental group followed a structured five-week program combining moderate-intensity aerobic and resistance training, totaling 150 minutes per week, and supervised by physiotherapists. Exercise intensity was monitored using the Borg and OMNI-Res perceived exertion scales, with prior familiarization sessions provided. Adherence was supported through attendance tracking, reminder messages, and motivational feedback. Unlike previous studies focused on fatigue or quality of life, this protocol targeted pain modulation based on neurophysiological mechanisms. Sessions included step-based aerobic routines and resistance exercises with bands, with clear safety and effort guidelines in place. No drugs or devices were used during the intervention.

Treatment:

Other: Exercise

Control Group

No Intervention group

Description:

Participants maintained usual activities for five weeks without changing exercise habits. No additional interventions (drugs, devices, or procedures) were applied.