MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease

Oelisoa Andriankaja

Status

Not yet enrolling

Conditions

Obesity

Dental Care for Children

Treatments

Behavioral: Oral Hygiene Instruction (OHI)

Procedure: Dental Cleaning and Oral Hygiene Instruction (OHI)

Study type

Interventional

Funder types

Other

Identifiers

NCT07478653

108598 (Other Identifier)

Details and patient eligibility

About

The goal of this clinical trial is to assess whether adjunctive dental cleaning can enhance the effects of semaglutide in children with obesity. The main question[s] it aims to answer [is/are]:

if dental cleaning will improve both oral health and metabolic outcomes beyond the effects of semaglutide alone.

Participants will receive either dental cleaning and oral hygiene instruction or oral hygiene instruction alone.

Full description

Parent study NCT06967389

Enrollment

50 estimated patients

Sex

All

Ages

12 to 17 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

participants from the ongoing Mitigation of Cardiovascular Disease Risks in Children with Extreme Obesity (MODERN) study (NCT06967389)
Class 2 or 3 obesity (BMI =120% of the 95th percentile for age and sex)

Exclusion criteria

Same exclusion as parent study.
Planning to receive or complete dental services during the 12-month course of the study
Ongoing orthodontic treatment
Use of any anti-inflammatory medication (other than steroids) within 1 month prior to enrollment
Currently taking medications that could influence the characteristics or response to periodontal treatment (e.g., use of immunosuppressants or steroids)
Local or systemic antibiotic use within 15 days prior to enrollment or for >10 days within the past 3 months
History of bleeding disorders
Professional dental prophylaxis or non-surgical periodontal therapy within the past 6 months