Modifiable Predictors of Neural Vulnerabilities for Obesity

University of Nebraska

Status

Completed

Conditions

Obesity

Treatments

Other: Milkshake fMRI

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT04522947

20317

R01DK125651 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to examine patterns of neural activation in a priori selected brain regions associated with reward process during anticipation and delivery of appetizing food stimuli (milkshake sips) among young adults.

Full description

This observational trial seeks to examine neural activation patterns in a food reward sensitivity task. The study uses the "milkshake" MRI task to assess individual food reward sensitivity in a sample of young adult participants. Participants are presented with a series of trials in which a visual cue is provided (either a glass of milkshake or water), followed by delivery of a sip of the corresponding liquid. Activation in a priori regions associated with reward processing is measured via blood oxygen level-dependent (BOLD) signal, both in response to the cue and actual delivery of the sip. Explicating patterns of reward processing for appetizing food stimuli holds potential to inform understanding of the neural underpinnings of obesity risk.

Enrollment

187 patients

Sex

All

Ages

19+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 19 years or older
Previous participation in the Preschool Problem Solving Study OR lived in Lancaster County, NE for at least part of high school

Exclusion criteria

Contraindications for functional magnetic resonance imaging (fMRI):
metal in body
pregnancy
braces
non-removal piercings
hair extensions
As of 8/13/21, for individuals who were not in the Preschool Problem Solving Study but are invited to participate in the current study because they lived in Lancaster County for at least part of high school, the maximum age for eligibility is 20 years of age.