Modification of Posttetanic Count (PTC) for Monitoring Deep Neuromuscular Block II

Rigshospitalet

Status and phase: Completed; Phase 4

Conditions: Neuromuscular Blockade

Treatments: Procedure: Post-tetanic count frequency

Study type: Interventional

Funder types: Other

Identifiers

NCT00390507

PTC-II

Details and patient eligibility

About

The purpose of this study is to examine the relationship between post-tetanic count (PTC) and time to first response to Train of four (TOF) stimulation during deep neuromuscular blockade induced by rocuronium.

Enrollment: 45 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1-3
• General anaesthesia >1 hour
• Surgery in supine position with possibility of monitoring the neuromuscular blockade at the thumb (n.ulnaris stimulation).
• Written informed content

Exclusion criteria

• Neuromuscular disorders, hepatic and renal dysfunction
• Medication expected to interfere with the neuromuscular blocking agent
• Allergy to any medication used during anaesthesia
• Body weight less or exceeding 20% of the ideal body weight
• Pregnancy or breastfeeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind