Modified Atkins Diet in Children and Adolescents With Drug-resistant Epilepsy

University of Oslo (UIO)

Status

Completed

Conditions

Epilepsy

Treatments

Other: The Modified Atkins Diet

Study type

Interventional

Funder types

Other

Identifiers

NCT01278966

S-09180a (REK)

Details and patient eligibility

About

The purpose of the study is to evaluate the effect of the Modified Atkins Diet in children and adolescents with drug-resistant epilepsy regarding seizure control, and to create a protocol for the use of the Modified Atkins Diet as a treatment for epilepsy in Norway.

Full description

The study is a prospective trial on the Modified Atkins Diet for children and adolescents with drug-resistant epilepsy. The Modified Atkins Diet is a less restrictive diet than the classical ketogenic diet, which is usually offered to this group of patients. Twenty patients between 2 and 18 years are included in the study, and the study period is 6 months. The study will be conducted at the National Centre for Child Epilepsy in Norway.

Enrollment

21 patients

Sex

All

Ages

2 to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age: 2-18 years
At least 3 epileptic seizures per week
Tried at least two anti-epileptic drugs without satisfactory seizure control
Willing to try diet treatment for 6 months

Exclusion criteria

Too difficult for the family to adhere to a strict diet
Not able to fill in a seizure calendar
Local authorities will not approve the treatment
VNS stimulator the last 12 months or changes made to VNS stimulator during the last three months
Other disease where a diet high in fat is contra indicated
Diet treatment is not possible because of poor intake of food or fluids
Cortisol or other medication that influence energy metabolism or epileptic drug metabolism last month
Patient has the last month used alternative medicine which may influence the diet
Patient has tried the ketogenic fiet og Modified Atkins diet the last three years
pregnancy