Modified Diaphragmatic Plication Rectifies Dyspnea

Tongji University

Status: Completed

Conditions: Phrenic Nerve Injury

Treatments: Procedure: Modified diaphragmatic plication

Study type: Observational

Funder types: Other

Identifiers

NCT06775873

MDP 010

0347130 (Other Grant/Funding Number)

Details and patient eligibility

About

Traditional diaphragmatic plication (DP) surgery is employed to ameliorate respiratory function in patients with diaphragmatic paralysis, which is rather complicated. This study introduces a modified method of DP. The efficacy of modified diaphragmatic plication (MDP) in preventing, treating, and relieving dyspnea in patients with phrenic nerve resection or injury due to extensive surgical intervention or local tumor invasion will be evaluated.

Enrollment: 50 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Preoperative chest X-ray suggesting diaphragmatic eventration, for which therapeutic MDP was performed;
• Mediastinal tumors encircling the phrenic nerve that could not be dissected or phrenic nerve injury occurring during intraoperative dissection, for which prophylactic MDP was performed;
• Diaphragmatic eventration and dyspnea following mediastinal surgery, for which salvage MDP was performed.

Exclusion criteria

• Congenital diaphragmatic deformity or diaphragmatic weakness due to poor general nutritional status;
• Morbid obesity with a BMI greater than 35 kg/m2;
• Neuromuscular diseases, including amyotrophic lateral sclerosis and myasthenia gravis;
• A history of upper abdominal surgery; and (5) Diaphragmatic calcification or fibrosis.