Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH

Eugonia

Status

Completed

Conditions

Infertility

Premature Ovarian Failure

Treatments

Drug: recombinant FSH (Puregon, Organon, The Netherlands)

Drug: GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands)

Drug: hCG (Pregnyl, Organon, The Netherlands)

Study type

Observational

Funder types

Other

Identifiers

NCT00417157

MNC

Details and patient eligibility

About

The purpose of this study is to evaluate the effectiveness of a modified natural cycle in patients with previous poor response to infertility drugs and high basal FSH, prior to proceeding to oocyte donation or abandoning fertility treatment.

Full description

Poor responders are a diverse group of IVF patients who fail to respond to IVF drugs. In these patients pregnancy rates remain disappointingly low and usually oocyte donation is their only viable option. The need for lengthy ovarian stimulation regimes can be avoided by performing IVF during a natural menstrual cycle. However, the main problem with a natural cycle is that successful IVF outcome can be compromised by a premature LH surge. This problem can be solved by the administration of GnRH antagonists that suppress endogenous gonadotropin levels, comprising a modified natural cycle (MNC). Previous studies have shown that MNC offers no realistic chances of pregnancy prior to oocyte donation. In this study we will re-assess this view by showing that MNC offers some, albeit small, chances of positive IVF outcome in patients with known previous poor response prior to oocyte donation.

Enrollment

135 patients

Sex

Female

Ages

20 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria