Modified Ultrafiltration in Cardiac Surgery

Goethe University

Status: Completed

Conditions: Transfusion Requirements; Coagulopathy; Blood Loss; Rethoracotomy

Treatments: Device: modified ultrafiltration using Maquet haemoconcentrator, BC 20 plus

Study type: Observational

Funder types: Other

Identifiers

NCT00998647

370/08 MUF

Details and patient eligibility

About

The purpose of this study is to find out, whether filtration of the blood in patients undergoing cardiac surgery, beneficially influences the coagulation system.

Full description

The impact of modified ultrafiltration following extracorporeal circulation on primary and secondary hemostasis is controversial. In this study we intend to assess both, primary and secondary hemostasis prior to and after the usage of modified ultrafiltration. Primary hemostasis is assessed using Multiple Electrode Aggregometry (Multiplate) and secondary hemostasis is assessed performing thrombelastometry using the ROTEM device. Patients are preoperatively randomized to receive either modified ultrafiltration or no filtration.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing complex cardiac surgery procedures

Exclusion criteria

• none

Trial design

60 participants in 2 patient groups

with modified ultrafiltration

Description:

elective cardiac surgery patients undergoing complex surgical intervention: coronary artery bypass grafting AND valve surgery double valve surgery aortic surgery Re-Dos

Treatment:

Device: modified ultrafiltration using Maquet haemoconcentrator, BC 20 plus

without modified ultrafiltration

Description:

elective cardiac surgery patients undergoing complex surgical intervention: coronary artery bypass grafting AND valve surgery double valve surgery aortic surgery Re-Dos

Treatment:

Device: modified ultrafiltration using Maquet haemoconcentrator, BC 20 plus