Modifying Virtual Reality Analgesia With Low-Dose Pain Medication

University of Washington

Status: Unknown

Conditions: Virtual Reality Therapy

Treatments: Drug: Low-dose pain medication (Ketalar) and saline placebo

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01840774

43929

Details and patient eligibility

About

The purpose of this study is to determine how pain relief is modified when the investigators combine the Virtual Reality based Snow World game with certain pain medications.

Full description

This is a randomized, double-blind, placebo-controlled, within subject 2x2 factorial, repeated measures study. Research participants will play two versions of the Virtual Reality based video game "Snow World" and be given thermal and electrical stimulus. Each of two study visits will be identical with the exception of whether or not the participant will receive an iv infusion of a low dose pain medication or a saline placebo.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male and females between the age of 18 and 60 years
• Ability to communicate orally
• Ability to read and understand English
• Body Mass Index between 20-35

Exclusion criteria

• Women who are pregnant, trying to become pregnant, or who are breastfeeding
• History of alcohol or substance abuse
• Major medical illness; including history of migraine headaches, seizures, brain injury, or peripheral neuropathy
• Current use of analgesics including acetaminophen, non-steroidal anti-inflammatories, or opioids
• Predisposition to severe motion sickness
• Unusual sensitivity or lack of sensitivity to pain
• Urine toxicology positive for opioids or benzodiazepines

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

Low-dose pain medication

Active Comparator group

Description:

80min IV infusion of a low-dose pain medication

Treatment:

Drug: Low-dose pain medication (Ketalar) and saline placebo

saline placebo

Placebo Comparator group

Description:

80min IV infusion of a saline placebo

Treatment:

Drug: Low-dose pain medication (Ketalar) and saline placebo