Modulation of Metabolic Rate by Inorganic Nitrate
Status
Completed
Conditions
Resting Metabolic Rate
Treatments
Other: Glucose Uptake
Other: Nitrite infusion
Other: Resting metabolic rate
Details and patient eligibility
About
The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.
Enrollment
55 patients
Sex
All
Ages
18 to 50 years old
Volunteers
Accepts Healthy Volunteers
Inclusion and exclusion criteria
Inclusion Criteria:
Healthy volunteers
Exclusion Criteria Chronic medication Vegetarian Nicotine Users Known metabolic disease
Trial design
Primary purpose
Basic Science
Allocation
Randomized
Interventional model
Crossover Assignment
Masking
Double Blind
55 participants in 4 patient groups, including a placebo group
Sodium nitrate
Active Comparator group
Description:
0.1 mmol NaNO3 / kg bodyweight / day for three days.
Treatment:
Other: Resting metabolic rate
Other: Glucose Uptake
Sodium Chloride
Placebo Comparator group
Description:
0.1 mmol NaCl / kg bodyweight / day for three days.
Treatment:
Other: Resting metabolic rate
Other: Glucose Uptake
Sodium nitrite infusion
Active Comparator group
Description:
Sodium nitrite (NaNO2) at a rate of 1, 10 and 100 nmol kg-1 min-1 (10 minutes per dose) was infused intravenously.
Treatment:
Other: Nitrite infusion
Saline infusion
Placebo Comparator group
Description:
Saline at a rate corresponding to 1, 10 and 100 nmol NaCl kg-1 min-1 (10 minutes per dose) was infused intravenously.
Treatment:
Other: Nitrite infusion
Trial contacts and locations
1
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Data sourced from clinicaltrials.gov
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