Modulation of Reinforcement Learning

RWTH Aachen University

Status

Completed

Conditions

Impact of Oxytocin on Social Learning

Treatments

Drug: Oxytocin vs. Placebo

Study type

Interventional

Funder types

Other

Identifiers

12-033

Details and patient eligibility

About

This study aims to examine the modulation of neuronal and behavioural parameters of social reinforcement learning.

Enrollment

60 patients

Sex

Male

Ages

18 to 26 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age between 18 and 26 years
male
IQ>80
written informed consent
proband understands character, extent and individual consequences of the study
competent persons who are able to follow the instructions of the study personnel
for ASD patients: assured ASD diagnosis, comply of the ASD criteria ADI-R/ADOS-G

Exclusion criteria

prosopagnosia
anaphylaxis of oxytocin or other chemical substances
metal inside the body or other contraindications of mri scan
physical illness which can affect the examinations or endanger the proband
actual or assumed drug or alcohol abuse
persons who are accommodated in an institution because of court or administrative order
persons with a relationship of dependence to the sponsor or investigator
healthy probands: psychiatric disorder according to ICD-10-WHO F at the moment and in history, continuous drug-intake at time of measurements
patients with ASD: psychiatric disorder according to ICD-10-WHO F (except ASD disorder in patient group) during the last 12 month being not treated, continuous drug-intake at time of measurements (psychotropic medication), exception: stimulants used for treatment of attention disorders, if they can come off for the measurements