Molecular Analysis of 150 Lung Adenocarcinoma (LUNG-EST)

Civil Hospices of Lyon

Status: Unknown

Conditions: Lung Adenocarcinoma

Treatments: Genetic: Sequencing

Study type: Observational

Funder types: Other

Identifiers

NCT02843711

69HCL15_0161

Details and patient eligibility

About

LUNG-EST is a retrospective study including 152 patients who benefit from lung surgery during the years 2012 to 2013 at Hospices civils de Lyon and with a diagnosis of lung adenocarcinomas. For all patients, clinical data and histopathological data are available. The objective of this study is to characterize these lung adenocarcinomas by the LungCarta Panel using the mass spectrometry array Sequenom. This panel could identify 214 DNA mutations and/or frameshift insert/deletion among 26 oncogenes. Once included in the study, the adenocarcinomas are also included in a Tissue MicroArray (TMA) in order to perform immunohistochemical analysis. Immunohistochemical staining with innovative antibodies are correlated with clinical, histopathological and molecular data.

Our hypothesis is that this TMA could constitute a good tool to screen interesting protein's expression.

Enrollment: 152 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults
• lung adenocarcinoma
• Surgical specimen

Exclusion criteria

• not adenocarcinoma subtype of lung cancer
• Tumour biopsy
• insufficient material for DNA extraction

Trial design

152 participants in 1 patient group

Adenocarcinoma

Description:

Tumour samples coming from patients harboring a lung adenocarcinoma diagnosed at the Hospices Civils de Lyon. Tumour samples are coming from lung surgery.

Treatment:

Genetic: Sequencing