Molecular and Cellular Characterization of Skull Base Tumors
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Details and patient eligibility
About
The purpose of the study is to analyze biological samples and genetic material for basic science research investigating the molecular and cellular characterization of skull base tumors.
Full description
The overall goal of this proposal is to determine new molecular and cellular features that define tumor subtypes that are clinically actionable, may drive important changes in patient management, and/or elucidate novel chemotherapeutic options. Skull base tumors are currently diagnosed based on histopathologic criteria, on which post-operative management is based. However, the investigators hypothesize that each tumor type (eg. chordoma or chondrosarcoma) will have molecular and/or cellular subcategories that will redefine how to categorize and diagnose patients, predict clinical outcome, and optimally design a patient-specific management strategy. In addition, we aim to catalogue changes that occur after treatment after surgical resection, chemotherapy, and/or radiation by comparing primary and recurrent tumors.
Enrollment
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Volunteers
Inclusion criteria
- Diagnosis of a skull base tumor
Exclusion criteria
- Insufficient tumor sample at time of resection
Trial contacts and locations
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Central trial contact
Benita Valappil, MPH
Data sourced from clinicaltrials.gov
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