Molecular and Cellular Mechanisms of the In-stent-thrombosis

RWTH Aachen University

Status: Withdrawn

Conditions: Patients With SAT or LT After Stent Implantation (PCI)

Study type: Observational

Funder types: Other

Identifiers

NCT00652015

EK 039/08

Details and patient eligibility

About

In-Stent-Thrombosis is a rare but serious complication after implantation of stents during PTCA.

Full description

In this prospective, open, not-randomized, controlled single-center pilot study 80 patients having had an in-stent-thrombosis (40 sub-acute thromboses (SAT), 40 late thromboses (LT)) and a control group of 80 patients having not developed a thrombosis will be compared.

The aim of this study is the establishment of diagnostic markers vor prediction of SAT (detection of CD39- and CD73-activity, respectively)and of LT (EPC-number and function, respectively) correspondingly aiming at the early identification of patients with high risk for developing an in-stent-thrombosis.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients having developed an SAT or LT after stent implantation using PTCA

Exclusion criteria

• instabel coronary heart diseases,
• systemic autoimmune diseases,
• rheumatic diseases,
• tumors,
• impaired kidney or liver function,
• surgery within the last 3 months,
• pregnant or lactating women

Trial design

0 participants in 2 patient groups

1

Description:

Patients having developed an in-stent-thrombosis (40 SAT, 40 LT)

2

Description:

Patients having not developed an in-stent-thrombosis after stent implantation using PTCA