Molecular and Microbiota Signatures Underlying Colonic Diverticular Disease (GR-Barbaro)

Scientific Institute for Research Hospitalization and Healthcare (IRCCS)

Status: Active, not recruiting

Conditions: Diverticular Disease of Colon

Treatments: Other: This is an observational study, participants are not assigned an intervention as part of the study.

Study type: Observational

Funder types: Other

Identifiers

NCT06764550

GR-2018-12367062 (Other Grant/Funding Number)

GR-Barbaro

Details and patient eligibility

About

The pathogenesis of diverticular disease is likely multifactorial in origin. This project aims to study the involvement of environmental factors in the pathophysiology of diverticular disease, the underlying molecular mechanisms, and alterations in the microbiota.

Full description

The pathogenesis of diverticular disease is likely multifactorial in origin. Some studies have demonstrated the role of genetic factors, while others have highlighted the role of environmental factors. The present project aims to study the involvement of environmental factors in the pathophysiology of diverticular disease, the underlying molecular mechanisms, and alterations in the microbiota.

Enrollment: 150 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 18 and 75 years.

• Belonging to one of the following groups:

  1. Patients with diverticula of the colon without symptoms.
  2. Patients symptomatic for diverticular disease.
  3. Subjects undergoing colonoscopy for colorectal cancer prevention or follow-up of previous polypectomies, asymptomatic for digestive symptoms.

• Obtaining informed consent.

Exclusion criteria

• Acute complicated diverticulitis (bleeding, perforation)
• Previous colon surgery
• Antibiotics or laxatives within the past 90 days
• Pregnancy and/or lactation
• Systemic and psychiatric disorders
• Asthma, food allergies and other allergic-type disorders
• Possible diseases leading to intestinal bacterial contamination (diabetes, blind loop syndrome, rheumatologic diseases).

Trial design

150 participants in 3 patient groups

Healthy subjects

Description:

Subjects who are asymptomatic for digestive symptoms and without diverticula.

Treatment:

Other: This is an observational study, participants are not assigned an intervention as part of the study.

Patients with diverticulosis

Description:

Patients with diverticula and without symptoms.

Treatment:

Other: This is an observational study, participants are not assigned an intervention as part of the study.

Patients with symptomatic uncomplicated diverticular disease

Description:

Patients with diverticula and with symptoms.

Treatment:

Other: This is an observational study, participants are not assigned an intervention as part of the study.