Molecular and Structural Comparison of Hypospadic and Normal Children Prepuces

Trakya University

Status: Completed

Conditions: Hypospadias

Study type: Observational

Funder types: Other

Identifiers

NCT03838458

Hypospadic prepuce structure

Details and patient eligibility

About

The aim of this study is to compare prepuce tissue samples from healthy male children who applied for circumcision and children with isolated hypospadias. Estrogen receptor 1 (ER1), androgen receptor (AR), FGFR2, transforming growth factor beta (TGF beta) and HOXA13 gene expression in the prepuce is planned to investigate via polymerase chain reaction (PCR) method. Mucosal vascular and nerve densities, and extracellular matrix density of laminin and collagen protein is planned to investigate via immunohistochemical examination.

Enrollment: 52 patients

Sex: Male

Ages: Under 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• To apply for circumcision, not to have any genitourinary abnormalities/conditions for control group.
• To have isolated hypospadias for study group.

Exclusion criteria

• To have genitourinary surgery before.

Trial design

52 participants in 2 patient groups

Study

Description:

Children with isolated hypospadias

Control

Description:

Children with planned circumcision