Molecular Characterization of Carbapenemase-Producing Enterobacterales

Sohag University

Status: Not yet enrolling

Conditions: Acute Myeloid Leukemia

Treatments: Diagnostic Test: Antibiotic administration; Diagnostic Test: Molecular detection of antibiotic resistance

Study type: Interventional

Funder types: Other

Identifiers

NCT07116356

Soh-Mmed-25-7-10PD

Details and patient eligibility

About

Bacterial infections with carbapenem resistant pathogens are one of the major threats in immunocompromised patients, especially among cancer patients .Furthermore, Gram negative pathogens are becoming increasingly prevalent and have become an ongoing global health concern .Emergence of Gram-negative pathogens, especially Enterobacterales that avert many of the human defense mechanisms are alarmingly increasing and most of these pathogens are resistant to many of the in-use antibiotics including carbapenems .

Enrollment: 100 estimated patients

Sex: All

Ages: 4 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients admitted to Sohag Oncology Center have different infections and isolated organism one of carbapenem resistant enterobacterales detected by antibiotic sensitivity test.

Exclusion criteria

• All patients admitted to Sohag Oncology Center having infections in different sites and isolated organisms are not one of enterobacterales and not carbapenem resistant.

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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100 participants in 2 patient groups

Group 1 Patients with enterobacterials infections

Experimental group

Treatment:

Diagnostic Test: Molecular detection of antibiotic resistance

Diagnostic Test: Antibiotic administration

Group 2 patients with other bacterial infections

Experimental group

Treatment:

Diagnostic Test: Molecular detection of antibiotic resistance

Diagnostic Test: Antibiotic administration