Molecular Characterization of Induced Neuronal Cells in Parkinson's Disease

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Parkinson Disease

Treatments: Procedure: Skin biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT05797779

3482

Details and patient eligibility

About

To describe the molecular, electrophysiological and morphological expression profile of dopaminergic neurons derived from fibroblasts of patients with Parkinson's disease.

Enrollment: 45 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Subjects aged 18 years or older
2. Patients with Parkinson's disease, according to the most recent diagnostic criteria
3. Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the study

Exclusion criteria

1. Patients affected by drug-induced parkinsonism or atypical parkinsonian disorders
2. Patients with neurological diseases other than Parkinson's disease
3. Inability to sign an informed consent
4. Severe psychiatric diseases

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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45 participants in 1 patient group

Skin biopsy

Experimental group

Treatment:

Procedure: Skin biopsy