Molecular Diversity of HIV-1 Group O Strains and Treatment Management in Cameroon

ANRS, Emerging Infectious Diseases

Status

Completed

Conditions

HIV Infections

Treatments

Drug: Treatment initiation for HIV-1 group M infected patients

Drug: Treatment initiation for HIV-1 group O infected patients

Study type

Observational

Funder types

Other

Identifiers

NCT00658346

ANRS 12168 DYNA M-O

Details and patient eligibility

About

Infections with HIV-1 group O are found in 1 to 3 % of persons living with HIV in Cameroon. The natural history and treatment response is not well understood. The natural resistance to non nucleoside reverse transcriptase inhibitors and their possible low sensitivity to protease inhibitors complicate the choice of an adequate treatment options.

This observational study is aimed at evaluating the antiretroviral treatment response of HIV-1 group O infected patients in comparison with HIV-1 group M infected patients. The proposed standardized follow-up will facilitate a better understanding of the natural history and treatment specificities to improve the patients management.

This is a non randomized study, open label, with standardized follow-up. A total of 171 patients

Enrollment

141 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

HIV-1 group O or group M infection
No history of antiretroviral treatment (except for PMTCT)
Criteria for treatment initiation according to the Cameroons national guidelines

Exclusion criteria