Molecular Epidemiology, Strains Genotyping of Multi-drug Resistant Tuberculosis Circulating in Central Africa Region (MESTCAR)

Centre de Recherche Médicale de Lambaréné

Status: Begins enrollment this month

Conditions: Central Africa; Multi Drug Resistant Tuberculosis; Strains; Molecular Epidemiology; Tuberculosis, Multi Drug Resistant

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT07017803

CEI-004/2025

Details and patient eligibility

About

Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge in Central Africa. Understanding the molecular epidemiology and genotypic characteristics of MDR-TB strains is crucial for effective control measures. This is highlighted by the emergence of mutations encoding resistance to bed aquiline and quinolones which may impact the roll out of the newly recommended Bedaquiline, Pretomanid, Linezolid and Moxifloxacin (BPaLM) regimens.

It is also worth noting that there is increasing evidence of the significance of TB lineage in the outcome of infection, the approach in the study will provide both information on chains of transmission and lineage.

Enrollment: 460 estimated patients

Sex: All

Ages: 9+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All GeneXpert positive TB patients and participants who provide written informed consent will be screened for the study. Participants aged above 8 who can provide sputum will also be screened.
• Patients enrolled in the tuberculosis epidemiology (TB-EPI) study and eligible for MESTCAR will be enrolled without any additional consent form as the data to be collected for the two studies will be shared and no additional process is needed.

Exclusion criteria

• Samples which do not meet the quality criteria.

  • Samples not enough to perform all of the laboratory process
  • Samples contaminated