Molecular Hydrogen for Cognitive Function and Performance in Elderly

University of Novi Sad, Faculty of Sport and Physical Education

Status and phase: Completed; Phase 3

Conditions: Aging; Cognitive Impairments

Treatments: Other: Molecular Hydrogen

Study type: Interventional

Funder types: Other

Identifiers

NCT02830854

DK-DR16-02

Details and patient eligibility

About

A variety of non-pharmacological interventions have been used in the management of Alzheimer's disease (AD) and similar cognitive disorders in elderly, yet no therapeutic modality has demonstrated conclusive positive results in terms of effectiveness. Although it is still unknown what triggers AD, recent studies have shown that AD is associated with brain energy depletion, oxidative stress, and mitochondrial dysfunction. Since supplemental molecular hydrogen (H2) supports cell energy production and acts as a highly bioavailable mitochondria-related antioxidant, it may provide an ideal agent to facilitate treatment and perhaps prevention of AD and similar cognitive disorders in elderly. The overall hypothesis to be evaluated in this project is that administration of H2 will positively affect patient-reported outcomes and clinical biomarkers in men and women suffering from AD.

Enrollment: 13 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age over 65
• No psychiatric comorbidities

Exclusion criteria

• Use of dietary supplements 4 weeks before study commence

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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13 participants in 1 patient group

Molecular Hydrogen

Experimental group

Description:

Molecular hydrogen: 20 min per day of 3% H2 during 4 weeks

Treatment:

Other: Molecular Hydrogen