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Molecular Hydrogen for Cognitive Function and Performance in Elderly

U

University of Novi Sad, Faculty of Sport and Physical Education

Status and phase

Completed
Phase 3

Conditions

Aging
Cognitive Impairments

Treatments

Other: Molecular Hydrogen

Study type

Interventional

Funder types

Other

Identifiers

NCT02830854
DK-DR16-02

Details and patient eligibility

About

A variety of non-pharmacological interventions have been used in the management of Alzheimer's disease (AD) and similar cognitive disorders in elderly, yet no therapeutic modality has demonstrated conclusive positive results in terms of effectiveness. Although it is still unknown what triggers AD, recent studies have shown that AD is associated with brain energy depletion, oxidative stress, and mitochondrial dysfunction. Since supplemental molecular hydrogen (H2) supports cell energy production and acts as a highly bioavailable mitochondria-related antioxidant, it may provide an ideal agent to facilitate treatment and perhaps prevention of AD and similar cognitive disorders in elderly. The overall hypothesis to be evaluated in this project is that administration of H2 will positively affect patient-reported outcomes and clinical biomarkers in men and women suffering from AD.

Enrollment

13 patients

Sex

All

Ages

65+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age over 65
  • No psychiatric comorbidities

Exclusion criteria

  • Use of dietary supplements 4 weeks before study commence

Trial design

Primary purpose

Supportive Care

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

13 participants in 1 patient group

Molecular Hydrogen
Experimental group
Description:
Molecular hydrogen: 20 min per day of 3% H2 during 4 weeks
Treatment:
Other: Molecular Hydrogen

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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