Molecular Markers and Genetic Markers in Patients Undergoing Radiation Therapy for Cancer

Rutgers The State University of New Jersey

Status: Withdrawn

Conditions: Unspecified Adult Solid Tumor, Protocol Specific; Hematopoietic/Lymphoid Cancer; Unspecified Childhood Solid Tumor, Protocol Specific

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00899808

P30CA072720 (U.S. NIH Grant/Contract)

000609

CINJ-IRB-0220060141

CDR0000592887

Details and patient eligibility

About

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at molecular markers and genetic markers in patients undergoing radiation therapy for cancer.

Full description

OBJECTIVES:

Primary

• Determine local-regional control in patients undergoing radiation therapy for cancer, as a function of expression of specific molecular/genetic markers.

Secondary

• Determine complications of radiation therapy for patients undergoing radiation therapy for cancer.

OUTLINE: Previously collected tissue samples are analyzed using immunohistochemical staining and other molecular/genetic study methods to detect markers, including p53, cyclin D1, HER-2-neu, bcl-2/BAX, and EGFR. Patient charts are also reviewed with emphasis on local-regional relapse.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Diagnosis of cancer
• Undergoing radiation therapy for malignant disease

PATIENT CHARACTERISTICS:

• Not specified

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics