Molecular Markers in Predicting Lung Cancer Development Using Tissue Samples From Healthy Participants

Vanderbilt University Medical Center

Status: Completed

Conditions: Healthy, no Evidence of Disease; Lung Cancer

Treatments: Procedure: bronchoscopy; Genetic: proteomic profiling; Other: biologic sample preservation procedure; Other: laboratory biomarker analysis

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00899457

P30CA068485 (U.S. NIH Grant/Contract)

P50CA090949 (U.S. NIH Grant/Contract)

VICC THO 0734

VICC-THO-0734

VU-VICC-THO-0734

Details and patient eligibility

About

RATIONALE: Studying samples of blood, urine, sputum, mouth cells, and bronchial tissue from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about the development of cancer.

PURPOSE: This laboratory study is looking for molecular markers in predicting lung cancer development using tissue samples from healthy participants.

Full description

OBJECTIVES:

• To obtain biological specimens from healthy participants with no known risk of lung cancer to use as controls in the study of lung cancer progression.
• To identify new molecular abnormalities specific to the development of squamous cell carcinoma of the lung.

OUTLINE: Serum, urine, sputum, and buccal cell samples are collected. Patients also undergo bronchoscopy for collection of bronchial tissue and bronchial brush samples. The samples are used for genomic and proteomic studies to identify new molecular abnormalities specific to the development of lung cancer.

Enrollment: 37 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

• Healthy participant

  • No history of smoking
  • No history of cancer

PATIENT CHARACTERISTICS:

• SWOG performance status 0
• No clinically apparent bleeding diathesis

PRIOR CONCURRENT THERAPY:

• Not specified

Trial design

37 participants in 1 patient group

Healthy, non-smokers

Treatment:

Procedure: bronchoscopy

Genetic: proteomic profiling

Other: biologic sample preservation procedure

Other: laboratory biomarker analysis