Molecular Mechanism Identification in Inherited Arrhythmias and Valvulopathies From Induced Pluripotent Stem Cells (Diag-iPS)

Nantes University Hospital (NUH)

Status: Terminated

Conditions: Inherited Arrhythmias and Valvulopathies

Treatments: Other: Skin biopsies

Study type: Interventional

Funder types: Other

Identifiers

NCT01734356

BRD/10/11-P

Details and patient eligibility

About

The recent developments of research on iPS (induced pluripotent stem) cells lead to the establishment of mature cell lines such as cardiomyocytes or valvular interstitial cells with genetic and cellular characteristics of the donors. These cells represent a biological material more readily available to identify the pathophysiological mechanisms involved in the diseases of BrS or ERS patients, which will lead to the identification of genetic markers.

Enrollment: 20 estimated patients

Sex: All

Ages: 22 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient with a family history of inherited arrhythmia or valvulopathy
• Age : 22-60 yo.
• patient no confine to bed
• Male or female
• Written consent
• Patient affiliated to the French social security

Exclusion criteria

• Pregnant woman
• Patient under 22 yo or adults under guardianship
• Indication against local anesthesia
• Anticoagulant treatment
• Absence or positivity of HIV, HBV, HCV serology

Trial design

20 participants in 3 patient groups

inherited arrhythmias

Other group

Description:

6 patient with inherited arrhythmias

Treatment:

Other: Skin biopsies

valvulopathies

Other group

Description:

6 patient with valvulopathies

Treatment:

Other: Skin biopsies

controle

Other group

Description:

8 healthy people for these pathologies

Treatment:

Other: Skin biopsies