Molecular Mechanisms of Raspberries Effect on Insulin Resistance and Inflammation (RASPBERRY)

Pennington Biomedical Research Center

Status: Completed

Conditions: Inflammation; Insulin Resistance

Treatments: Other: Raspberries

Study type: Interventional

Funder types: Other

Identifiers

NCT04306406

2015-0004

Details and patient eligibility

About

Red raspberries (Rubus idaeus) are a good source of health enhancing hydrolyzable and condensed tannins, flavonoids, anthocyanins, phenolic acids, rheosmin, potassium, carotenoids, vitamin C, and vitamin K1. Compared to other berries commonly consumed in the US, the health benefits of red raspberries to improve pre-diabetes mellitus (PDM) and type 2 diabetes have never been explored. The clinical study proposed in this project seeks to investigate the protective effect of whole red raspberries against insulin resistance, oxidative stress, and inflammation in PDM and type 2 diabetic patients. The in vitro study proposed in the project will assist in identifying the molecular mechanisms by which whole red raspberry protect islet cells against oxidative stress, insulin resistance and loss of cell function.

Enrollment: 9 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• type 2 diabetes

Exclusion criteria

• hypoglycemic agents
• Pregnant or nursing a child
• chronic medication that does not have a stable dose for greater than one month
• anti-inflammatory medication
• inflammatory disease

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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9 participants in 1 patient group

Raspberry Smoothies

Other group

Description:

Single serving smoothies drink made with red raspberries to be consumed daily for two weeks

Treatment:

Other: Raspberries