Molecular Mediators of Nerve Injury Signaling

Rambam Health Care Campus

Status: Unknown

Conditions: Chronic Neuropathic Pain; Diabetes; Nerve Injury

Study type: Observational

Funder types: Other

Identifiers

NCT01437332

0356-11-RMB

Details and patient eligibility

About

Specific proteins and other signaling molecules are increased and decreased following nerve injury. Some of these are important in producing pain or explaining why pain persists after traumatic nerve injuries or in disease states such as diabetes. In this study, the investigators hypothesize that it is possible to detect changes in specific signaling molecules and that these will provide insights into novel treatment strategies. The patients to be included are those who are undergoing the removal of tissue during surgery. The tissues that would otherwise be discarded will be included in the study as appropriate.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing surgery where tissue removal is anticipated

Exclusion criteria

• age younger than 18

Trial design

50 participants in 3 patient groups

Diabetes

Nerve injury

Other