Molecular, Pathologic Intra Tumoral Heterogeneity in Malignant Pleural Mesothelioma (SCITH-MESO)

Civil Hospices of Lyon

Status: Enrolling

Conditions: Pleural Mesothelioma; Mesothelioma, Malignant; Gene Abnormality

Treatments: Genetic: PLEURAL BIOCOLLECTION OF MALIGNANT PLEURAL MESOTHELIOMA

Study type: Observational

Funder types: Other

Identifiers

NCT04823741

2021-A00748-33 (Other Identifier)

69HCL20_0997

Details and patient eligibility

About

Malignant pleural mesothelioma (MPM) is a rare pleural cancer, which could be primary or secondary to an asbestos exposure. To enhance our knowledge of this rare disease, an exploration of genetic and tumor mechanism is mandatory. One of the principal difficulty is to harvest sufficient tumour pieces to perform multi-omics analysis. The goal of the SCITH-MESO study is to harvest larges pieces of tumour during a routine surgical procedure of MPM diagnosis by mean of pleural biopsies during VATS surgery. Operating samples will increase a tissue bank collection (CRB).

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age >18
• suspected MPM requiring VATS biopsy after multidisciplinary oncologic board validation
• patient able to understand study objectives and able to give an informed consent
• patient affiliated to an healthcare society.

Exclusion criteria

• pregnancy
• mental disease, psychiatric disorder
• patient under protection regimen

Trial design

30 participants in 1 patient group

PLEURAL BIOCOLLECTION OF MALIGNANT PLEURAL MESOTHELIOMA

Description:

All patient with suspected malignant pleural mesothelioma requiring surgical biopsy after validation in oncologic multidisciplinary board will be included. During a standardized routine procedure of pleural biopsy by mean of general anesthesia and video thoracoscopic approach, 3 - 5 biopsies are realized. During this procedure, blood samples are collected and a piece of biopsy will be used for the constitution of a specific bio collection in the CRB (centre de ressources biologiques).

Treatment:

Genetic: PLEURAL BIOCOLLECTION OF MALIGNANT PLEURAL MESOTHELIOMA