Molecular Phenotyping of Migraine Patients According to Sex and Age Through CGRP Quantification (FAST)

Vall d'Hebron University Hospital (HUVH)

Status

Enrolling

Conditions

Episodic Migraine Headache

Headache (Migraine)

Chronic Migraine Headache

Migraine with Aura

Migraine Headache

Chronic Migraine, Headache

Migraine Without Aura

Migraine

Episodic Migraine

Treatments

Diagnostic Test: Saliva test

Study type

Observational

Funder types

Other

Identifiers

NCT06674772

PR(AG)350/2022

Details and patient eligibility

About

Patients will be asked to visit the study center 2 times, the first time for clinical assessment and a second time for sample collection. Healthy controls will only be asked to visit the study center for sample collection. A sample of blood and saliva will be collected in order to measure CGRP levels and DNA and hormone testing.

Full description

CGRP is a neuropeptide related to migraine pathophysiology, which can be found in human saliva in both patients and healthy controls. The differences in CGRP levels may help us explain the differences in the treatment response.

A sample of saliva will be collected in order to measure CGRP levels and a blood sample will be collected in order to conduct a DNA test and hormones test.

Enrollment

440 estimated patients

Sex

All

Ages

6 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Migraine patients according to ICHD-3 criteria
Healthy controls paired to patient age and sex, without headache and without first degree family history of headache.

Exclusion criteria

Presence of any major medical or neurological illness.
Presence of any salivary gland malfunction.
Abuse or dependence to tobacco, alcohol or any drug in the previous 12 months before the enrollment.
Active migraine preventive treatment.
Pregnant or breastfeeding female.