Molecular Pituitary Imaging Using 18F-FET PET (FET-pit-PET)

University of Cambridge

Status: Enrolling

Conditions: Pituitary Adenoma

Treatments: Diagnostic Test: 18F-Fluoro-ethyl-tyrosine (FET) PET

Study type: Interventional

Funder types: Other

Identifiers

NCT06584123

24/LO/0542

Details and patient eligibility

About

The goal of this single centre pilot study is to explore whether 18F-fluoro-ethyl-tyrosine PET (FET-PET) yields comparable findings to 11C-methionine PET (Met-PET) for the localisation of pituitary tumours.

Full description

Up to 20 patients with pituitary adenomas (PA) who have previously undergone 11C-methionine PET (Met-PET) as part of routine clinical care will undergo 18F-fluoroethyltyrosine PET (FET-PET). Patients with newly diagnosed PA or residual/recurrent pituitary tumours following previous treatment will be eligible for recruitment to the study.

Quantitative and qualitative analyses will be performed to assess whether MET-PET and FET-PET yield comparable findings in patients with newly diagnosed or recurrent PA.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

• Participant is willing and able to give informed consent for participation in the study
• Male or female, age 18 or above
• Presence of pituitary adenoma suspected on the basis of clinical/biochemical and/or radiological findings
• Previous 11C-Met-PET/CT

Exclusion criteria

• Inability to give informed consent
• Pregnancy or suspected pregnancy
• Inability to lie supine for 30-60 minutes
• Patient body habitus above scanner dimensions
• Known allergy to intravenous radiographic contrast agents

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Study cohort

Experimental group

Description:

All patient's enrolled in the study will undergo an 18F-FET-PET

Treatment:

Diagnostic Test: 18F-Fluoro-ethyl-tyrosine (FET) PET