Molecular Profile of Thyroid Nodules (MPTN)

Belarusian State Medical University

Status: Not yet enrolling

Conditions: Thyroid Nodule; Thyroid Cancer

Treatments: Diagnostic Test: Molecular testing

Study type: Observational

Funder types: Other

Identifiers

NCT05323669

20220367

Details and patient eligibility

About

Profiling and comparative analysis of genomic alterations and miRNA expression in benign and malignant thyroid tumors using histological and cytological specimens will be performed. Obtained information is necessary to create a molecular test to refine the cancer risk of cytologically indeterminate thyroid nodules.

Full description

This is an non-randomised retrospective study consisting of 2 parts. Part A. Histological specimens (formalin fixed paraffin embedded) of patients who were operated on for benign and malignant thyroid disorders will undergo molecular testing to create a molecular profile of thyroid nodules characteristic of Belarusian population.

Part B. Fixed cytological smears of indeterminate thyroid nodules (categories III, IV and V according to Bethesda scoring system) of operated patients will undergo molecular testing to evaluate the possibility and reliability of molecular testing of fixed cytological smears using available assays.

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients operated on for malignant and benign thyroid tumors. Age is greater than or equal to 18 years old.

Exclusion criteria

no