Molecular Profiling of Colorectal Cancer

Hellenic Cooperative Oncology Group

Status: Unknown

Conditions: Colon Cancer; Colon Adenocarcinoma; Colorectal Cancer

Treatments: Diagnostic Test: Gene panel

Study type: Observational

Funder types: Other

Identifiers

NCT04863768

TR6N/19

Details and patient eligibility

About

In this translational research study, Formalin-Fixed-Paraffin-Embedded (FFPE) tumor tissue blocks from patients with early-stage (II-III) colorectal cancer will be assessed for a comprehensive cancer gene panel from NIPD Genetics (https://www.nipd.com/) targeting regions in 37 clinically relevant cancer genes.

The colorectal cancer panel includes an extended list of clinically relevant genes, designed to target clinically actionable and clinically significant mutations that will provide physicians with genetic information regarding a) prediction of the patient's response to targeted therapy, b) prognosis, that is, prediction of clinical outcome, c) diagnosis and molecular classification of colorectal cancer.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Surgically resected early-stage (II-III) colorectal cancer
• Availability of biological material

Exclusion criteria

• Metastatic disease (stage IV) at initial diagnosis